Introduction to the role of experimental design; basic statistical concepts; sampling and sampling distribution; Testing of hypotheses about differences in means- randomized designs and paired comparison designs; testing of hypotheses about variances Analysis of variance (ANOVA) -one-way classification ANOVA; analysis of fixed effects model; comparison of individual treatment means; the random effects model; the randomized complete block design Factorial design of experiments; two-factor factorial design-fixed effects and random effects
model; General factorial design; analysis of 2k and 3k factorial designs Conforming in the 2k factorial design in 2p block; confounding in the 3k factorial design in 3p block; Fractional replication of the 2k factorial design and the 3k factorial design Regression analysis- Simple and multiple linear regression and hypothesis testing; response surface methodology-the method of steepness ascent : response surface designs for first-order and second-order models. Evolutionary operation (EVOP).